Updates in Nutrition and Brain Health

Today's research summary reviews the impact of curcumin on neurodegenerative diseases and anxiety, a prospective study exploring the role of diet in multiple sclerosis onset, associations between ultra-processed foods and mental health outcomes, advances in treatment of avoidant restrictive food intake disorder, a systematic review of the beneficial effects of synbiotics on ADHD and more. Inclusive of publication dates 6/1/24-6/15/24.

Key: *Full text available **Section summaries available

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Sarah Ferreira, MS, MPH, RD

Topic Area

• Cognitive Function, Memory and Neurodegeneration

• Mood and Mental Health

• Eating Disorders

• Neurodevelopmental Outcomes

• Brain Injury

• Migraines, Epilepsy and Other Neurological

• Addiction, Eating Behavior and Food Choice

• Other

Cognitive Function, Memory and Neurodegeneration

*A comprehensive examination of the evidence for whole of diet patterns in Parkinson's disease: a scoping review

A high fat diet potentiates neonatal iron overload-induced memory impairments in rats

A marine-derived antioxidant astaxanthin as a potential neuroprotective and neurotherapeutic agent: A review of its efficacy on neurodegenerative conditions

*A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults-study design and baseline characteristics of the FINGER-NL randomized controlled trial

*Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial

Amelioration of walnut, peony seed and camellia seed oils against D-galactose-induced cognitive impairment in mice by regulating gut microbiota

*An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial

Association of aquatic food consumption, long-chain polyunsaturated n-3 fatty acid intake, and blood mercury levels with cognitive function in middle-aged and older adults

*Associations of vegetable and fruit intake with cognitive function and its decline: Two longitudinal studies

Causal associations of antioxidants with Alzheimer's disease and cognitive function: a Mendelian randomisation study

*Co-administration of probiotic and vitamin D significantly improves cognitive function in schizophrenic patients: A double-blinded randomized controlled trial

Concurrent nutrient deficiencies are associated with dementia incidence

*Correlation between 25-hydroxy-vitamin D and Parkinson's disease

Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study

*Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease

*Dietary Modification Combined with Nutrition Education and Counseling for Metabolic Comorbidities in Multiple Sclerosis: Implications for Clinical Practice and Research

**Dietary patterns and carotenoid intake: Comparisons of MIND, Mediterranean, DASH, and Healthy Eating Index

*Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial

*Effects of resistance exercise and whey protein supplementation on cognitive function in older men: secondary analysis of a randomised, double-blind, placebo-controlled trial

*Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review

Effects of Vitamin D Supplementation on Cognitive Outcomes: A Systematic Review and Meta-Analysis

*Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials

*Efficacy and safety of Ferrous iron on the prevention of Vascular cOgnitive impaiRment among patients with cerebral Infarction/TIA (FAVORITE): rationale and design of a multicentre randomised trial

Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer' s Disease Mouse Model

Enhancing Brain Health and Well-Being in Older Adults: Innovations in Lifestyle Interventions

*ESPEN guideline on nutrition and hydration in dementia - Update 2024

Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects

Food for thought: dietary nootropics for the optimisation of military operators' cognitive performance

**Fruit and Vegetable Intake and Risk of Disabling Dementia: Japan Public Health Center Disabling Dementia Study

*Genetically determined dietary habits and risk of Alzheimer's disease: a Mendelian randomization study

Glymphatic pathway: An emerging perspective in the pathophysiology of neurodegenerative diseases

Harvesting Health: Phytochemicals in Cognitive Impairment Therapy

*Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding

*Impact of a keto diet on symptoms of Parkinson's disease, biomarkers, depression, anxiety and quality of life: a longitudinal study

Impact of vegetarianism on cognition and neuropsychological status among urban community-dwelling adults in Telangana, South India: a cross-sectional study

Inhibition of fibril formation by polyphenols: molecular mechanisms, challenges, and prospective solutions

*Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial

Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice

*Milk fat globule membrane and its polar lipids: reviewing preclinical and clinical trials on cognition

*Modulation of Gut Microbiota Through Dietary Intervention in Neuroinflammation and Alzheimer's and Parkinson's Diseases

**Nature's Toolbox for Alzheimer's Disease: A Review on the Potential of Natural Products as Alzheimer's Disease Drugs

Neuroprotective and anti-inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies

*Neuroprotective Effects of Curcumin in Neurodegenerative Diseases

Nootropic supplements for esports

Polyphenols and Diets as Current and Potential Nutrition Senotherapeutics in Alzheimer's Disease: Findings from Clinical Trials

Population attributable fractions of modifiable risk factors for dementia: a systematic review and meta-analysis

*Propionic acid promotes neurite recovery in damaged multiple sclerosis neurons

Protective effect of unsaturated fatty acids on cognitive impairment in CKD patients: Results from the National Health and Nutrition Examination Survey (2011-2014)

*Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention

Review of the potential pharmacological role of erucic acid: a monounsaturated omega-9 fatty acid

Selenium Nanoparticles as Neuroprotective Agents: Insights into Molecular Mechanisms for Parkinson's Disease Treatment

Serum zinc concentration and dietary zinc intake in relation to cognitive function: an analysis of the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort

The Anti-Neuroinflammatory Effect of Extra-Virgin Olive Oil in the Triple Transgenic Mouse Model of Alzheimer's Disease

The connection between gut microbiota and its metabolites with neurodegenerative diseases in humans

*The impact of dietary acid load on super-agers with exceptional cognitive abilities: a propensity score analysis of national health and nutrition examination survey (NHANES) 2011-2014

*The Role of Diet in Multiple Sclerosis Onset: A Prospective Study Using UK Biobank

*The role of dietary fats on cognition and sarcopenia in the elderly

**The role of labile iron on brain proteostasis; could it be an early event of neurodegenerative disease?

The impact of sustainable diets οn cognitive function in an ageing society: A mini-review

The vicious circle between homocysteine, methyl group-donating vitamins and chronic levodopa intake in Parkinson's disease

Thymoquinone ameliorates symptoms of Parkinson's disease in a 6-OHDA rat model by downregulation of miR-204-3p

**Time-dependent effects of high-fat diet on cognition and cerebral insulin signaling: Window for recovery and potential therapeutic target

*Tributyrin reverses the deleterious effect of saturated fat on working memory and synaptic plasticity in juvenile mice: differential effects in males and females

Unlocking Quercetin's Neuroprotective Potential: A Focus on Bee-Collected Pollen

Mood and Mental Health

*A healthy dietary pattern is associated with microbiota diversity in recently diagnosed bipolar patients: The Bipolar Netherlands Cohort (BINCO) study

**Accelerated biological aging as potential mediator mediates the relationship between pro-inflammatory diets and the risk of depression and anxiety: A prospective analysis from the UK biobank

*Adherence to Mediterranean diet is inversely associated with depressive symptoms in older women: findings from the NutBrain Study

An Overview of the Potential Role of Nutrition in Mental Disorders in the Light of Advances in Nutripsychiatry

*Anti-depressant effect of Naringenin-loaded hybridized nanoparticles in diabetic rats via PPARγ/NLRP3 pathway

Association between consumption of fruits and vegetables in midlife and depressive symptoms in late life: the Singapore Chinese Health Study

**Association between eicosapentaenoic acid consumption and the risk of depressive symptoms in US adults: Analyses from NHANES 2005-2018

*Association between junk food consumption and mental health problems in adults: a systematic review and meta-analysis

*Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population

*Association of serum fatty acid pattern with depression in U.S. adults: analysis of NHANES 2011-2012

*Comparative study of eating behavior between patients with mental illness and healthy controls using the Japanese version of the Dutch Eating Behavior Questionnaire

Defining a vitamin A5/X specific deficiency - vitamin A5/X as a critical dietary factor for mental health

**Dietary sulforaphane glucosinolate mitigates depression-like behaviors in mice with hepatic ischemia/reperfusion injury: A role of the gut-liver-brain axis

Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials

Effects of Bifidobacterium breve 207-1 on regulating lifestyle behaviors and mental wellness in healthy adults based on the microbiome-gut-brain axis: a randomized, double-blind, placebo-controlled trial

**Effects of early-life stress followed by access to stevia or sucralose during adolescence on weight gain, glycemia, and anxiety-related behaviors in male and female rats

*Efficacy and safety of a mineral and vitamin treatment on symptoms of antenatal depression: 12-week fully blinded randomised placebo-controlled trial (NUTRIMUM)

*Exercise and Nutrition in the Mental Health of the Older Adult Population: A Randomized Controlled Clinical Trial

*Exploring the role of vitamin D in cognitive function: mediation by depression with diabetes modulation in older U.S. adults, a NHANES weighted analysis

*Evaluating the efficacy and mechanisms of a ketogenic diet as adjunctive treatment for people with treatment-resistant depression: A protocol for a randomised controlled trial

*Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses

Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study

Imbalance of Plasma Copper and Zinc Levels and the Association Between the Cu/Zn Ratio and Lipid Peroxidation in Algerian Bipolar Patients

*Lifestyle modification as intervention for seasonal affective disorder: A systematic review

*Mediterranean Diet Adherence, Physical Activity, and Advanced Glycation End Products in Complex PTSD: A Comprehensive Examination of Lifestyle and Cardiovascular Risk in War Veterans

Nutrition and schizophrenia: associations worthy of continued revaluation

*One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial

*Prenatal Iodine Intake and Maternal Pregnancy and Postpartum Depressive and Anhedonia Symptoms: Findings from a Multiethnic US Cohort

Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice

Regulation of gut microbiota and serum neurotransmitters in mice by Streptococcus thermophilus GA8- and Lacticaseibacillus rhamnosus HAO9-fermented milk containing high levels of gamma-aminobutyric acid

*Roles of selenium in cognition (Letter to the Editor)

*Sex-dependent effects of carbohydrate source and quantity on caspase-1 activity in the mouse central nervous system

The effect of a low-calorie diet on depressive symptoms in individuals with overweight or obesity: a systematic review and meta-analysis of interventional studies - ADDENDUM

*The effects of jujube (Ziziphus jujube) on metabolic and mental health outcomes in patients with metabolic syndrome: A randomized controlled trial

The higher dietary inflammation is associated with a higher burden of multimorbidity of cardio-metabolic and mental health disorders in an urbanizing community of southern India: A cross-sectional analysis for the APCAPS cohort

*Ultra-processed foods and human health: An umbrella review and updated meta-analyses of observational evidence

Understanding the experiences of ketogenic metabolic therapy for people living with varying levels of depressive symptoms: a thematic analysis

*Unraveling the gut-brain connection: The association of microbiota-linked structural brain biomarkers with behavior and mental health

Eating Disorders

*A novel weight suppression score associates with distinct eating disorder and ultra-processed food symptoms compared to the traditional weight suppression measure among adults seeking outpatient nutrition counseling

*A phase II randomised controlled trial of intranasal oxytocin in anorexia nervosa

*Avoidant restrictive food intake disorder: recent advances in neurobiology and treatment

Behavioral weight loss treatment for adults with binge-eating disorder: A qualitative analysis of patients' perspectives and experiences

*Cocreating eating disorder education solutions: A design thinking approach to dietetics curricula in Australia

*Determinants and risk factors for renal damage: where do patients hospitalized for severe anorexia nervosa stand? A multi-center study

*Eating Disorders In weight-related Therapy (EDIT) Collaboration: rationale and study design

*Engagement in binge eating and fasting associated with poorer sleep quality in an online sample of adults

Gastrointestinal diagnoses in patients with eating disorders: A retrospective cohort study 2010-2020

*Medical Nutrition Education for Health, Not Harm: BMI, Weight Stigma, Eating Disorders, and Social Determinants of Health

*Orthorectic behavior among students and motivation for physical activity, dietary habits, and restrictive eating

**Pediatric Intestinal Failure Associated Eating Disorder: An Overview of the Importance of Oral Feeding in a Population at Risk for Feeding Difficulties

*Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis

**The association between food neophobia, bi-dimensional aspects of orthorexia, and anxiety among vegetarians and omnivores

*The use of food barcode scanner app among women: Associations with orthorexia, diet and emotions

Visual art- and music-based interventions as adjuvants in the treatment of eating disorders: a systematic review and a theoretical model

Neurodevelopmental Outcomes

*A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats

*A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on ADHD

*Association of cord blood vitamin D with child neurodevelopment at 7 years of age

Clinical Correlates and Prevalence of Food Selectivity in Children with Autism Spectrum Disorder

Determination of Nutrient Intake and Dietary Antioxidant Capacity in Autism Spectrum Disorder: A Case-Control Study

**Dietary flavonoids modulate the gut microbiota: A new perspective on improving autism spectrum disorder through the gut-brain axis

Differential effectiveness of dietary zinc supplementation with autism-related behaviours in Shank2 knockout mice

*Dolphin CONTINUE: a multi-center randomized controlled trial to assess the effect of a nutritional intervention on brain development and long-term outcome in infants born before 30 weeks of gestation

*Early-life and chronic exposure to high-fat diet alters noradrenergic and glutamatergic neurotransmission in the male rat amygdala and hippocampus under cognitive challenges

*High protein intake on later outcomes in preterm children: a systematic review and meta-analysis

Independent and combined effects of astaxanthin and omega-3 on behavioral deficits and molecular changes in a prenatal valproic acid model of autism in rats

Role of one-carbon nutrient intake and diabetes during pregnancy in children's growth and neurodevelopment: A 2-year follow-up study of a prospective cohort

The effect of vitamin D supplementation on the brain mapping and behavioral performance of children with ADHD: a double-blinded randomized controlled trials

*The protective role of prenatal administration of ascorbic acid on autistic-like behavior in a rat model of autism

*Tiger nut/coconut dietary intervention as antidotal nutritional remediation strategy against neurobehavioural deficits following organophosphate-induced gut-brain axis dysregulation in mice

Vitamins B9 and B12 in children with attention deficit hyperactivity disorder (ADHD)

Brain Injury

Clinical Outcomes of Early Versus Late Enteral Nutrition Support in Critically Ill Trauma Patients With Isolated Traumatic Brain Injury

Crocetin protects mouse brain from apoptosis in traumatic brain injury model through activation of autophagy

Factors Influencing Omega-3 Index Status in Active-Duty Military Personnel

Nutrition and the gut-brain axis in neonatal brain injury and development

Predictors for Failed Removal of Nasogastric Tube in Patients With Brain Insult

*Selected serum cytokines and vitamin D levels as potential prognostic markers of acute ischemic stroke

Migraines, Epilepsy and Other Neurological

*Adherence to ketogenic dietary therapies in epilepsy: A systematic review of literature

*Benefits of Combining Antiepileptic Drugs with Vitamin B12 on Redox Balance: Penicillin-Induced Experimental Epilepsy Model

Changes in pediatric referrals after the 2009 ketogenic diet consensus recommendations

Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999-2004

*Effective reduction in seizure severity and prevention of a fatty liver by a novel low ratio ketogenic diet composition in the rapid kindling rat model of epileptogenesis

*Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study

Harnessing Therapeutic Potentials of Biochanin A in Neurological Disorders: Pharmacokinetic and Pharmacodynamic Overview

*Ketogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki syndrome

Lifestyle Behavioral Interventions and Health-Related Outcomes Among People with Epilepsy: A Review of Randomized Controlled Trials

*Migraine incidence and coffee consumption among child-bearing age women: the Korea Nurses' Health Study

The impact of ketogenic diet on drug-resistant epilepsy in children: A comprehensive review and meta-analysis

The role of caffeine in headache disorders

*The use of ketogenic diets in children living with drug-resistant epilepsy, glucose transporter 1 deficiency syndrome and pyruvate dehydrogenase deficiency: A scoping review

**Therapeutic Potential of the Ketogenic Diet: A Metabolic Switch with Implications for Neurological Disorders, the Gut-Brain Axis, and Cardiovascular Diseases

Typical and atypical MRI abnormalities in Wernicke's encephalopathy: Correlation with blood vitamin B1 levels

Vitamin D Relieves Epilepsy Symptoms and Neuroinflammation in Juvenile Mice by Activating the mTOR Signaling Pathway via RAF1: Insights from Network Pharmacology and Molecular Docking Studies

*Zinc Administration Favorably Affects Prophylactic Therapy-refractory Migraine Attacks: A Case Series

Addiction, Eating Behavior and Food Choice

**Altered neural representation of olfactory food reward in the nucleus accumbens after acute stress

*Association between watching eating shows and unhealthy food consumption in Korean adolescents

*Association of MC4R rs17782313 Genotype With Energy Intake and Appetite: A Systematic Review and Meta-analysis

*Development and psychometric testing of the nutritional and social health habits scale (NutSo-HH): A methodological review of existing tools

*Diet quality and associations with motivation and ability to consume a healthy diet among adolescents from urban low-income households in Bangladesh

Dietary and quality-of-life outcomes of the FoodFix intervention for addictive eating: a short report

Dietary intake in children and adolescents with food addiction: A systematic review

Effect of time restricted feeding on anthropometric measures, eating behavior, stress, serum levels of BDNF and LBP in overweight/obese women with food addiction: a randomized clinical trial

*Free to be Healthy? Free Will Beliefs are Positively Associated With Health Behavior

*GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia

Gamification preferences in nutrition apps: Toward healthier diets and food choices

*Hedonic hunger, eating behavior, and food reward and preferences 1 year after initial weight loss by diet or bariatric surgery

Lateral parabrachial nucleus astrocytes control food intake

Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity

Personal values, food habits and lifestyles in a sample of adolescents with different adherence to the Mediterranean Diet

*Self-reported decreases in the purchases of selected unhealthy foods resulting from the implementation of warning labels in Mexican youth and adult population

*The impact of packaging attributes on portion decisions: Consumer values are important

*Unveiling the lockdown effects: exploring behavior, dietary habits and weight changes in rural Egypt during COVID-19 lockdown: a cross-sectional retrospective study

*Ventral Tegmental Area Amylin Receptor Activation Differentially Modulates Mesolimbic Dopamine Signaling in Response to Fat versus Sugar

*What factors influence sustainable and healthy diet consumption? A review and synthesis of literature within the university setting and beyond

Other

Associations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes

*Preventing hyperhomocysteinemia using vitamin B6 supplementation in Givosiran-treated acute intermittent porphyria: Highlights from a case report and brief literature review

Psychological, Psychiatric, and Organic Brain Manifestations of Celiac Disease

Resveratrol Reduces Neuroinflammation and Hippocampal Microglia Activation and Protects Against Impairment of Memory and Anxiety-Like Behavior in Experimental Cerebral Palsy

The Ameliorative and Neuroprotective Effects of Dietary Fiber on Hyperuricemia mice：A perspective from Microbiome and Metabolome

**Vitamin C deficiency alters the transcriptome of the rat brain in a glucocorticoid-dependent manner, leading to microglial activation and reduced neurogenesis

Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress

Wernicke Encephalopathy After Roux-en-Y Gastric Bypass Presenting with Altered Mental Status-A Video Case Report

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Copyright © 2024 Sarah Thomsen Ferreira.