Brain Food Digest: July 1-15, 2024

What's New in Nutrition and Brain Health

Today's research summary includes an update on caffeine consumption outcomes in ALS progression, an exploration of nutrients associated with prenatal sleep quality, a systematic review exploring the role of complementary and alternative medicine (CAM) for autism spectrum disorder, and much more. Inclusive of publication dates July 1-15th, 2024.

Key: *Full text available **Section summaries available

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Sarah Ferreira, MS, MPH, RD

Research Area

• Cognitive Function, Memory and Neurodegeneration

• Mood and Mental Health

• Eating Disorders

• Addiction, Eating Behavior and Food Choice

• Neurodevelopmental Outcomes

• Sleep Health and Insomnia

• Brain Injury

• Migraines, Epilepsy and Other Neurological

• Other

Cognitive Function, Memory and Neurodegeneration

Aloe polysaccharides ameliorate obesity-associated cognitive dysfunction in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity

Amelioration of Amyloid-β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3β/Wnt/β-Catenin Signaling

*Ascorbate insufficiency disrupts glutamatergic signaling and alters electroencephalogram phenotypes in a mouse model of Alzheimer's disease

Association between serum magnesium levels and cognitive function in patients undergoing hemodialysis

Association of Higher Mediterranean Diet Adherence With Lower Prevalence of Disability and Symptom Severity, Depression, Anxiety, Stress, Sleep Quality, Cognitive Impairment, and Physical Inactivity in Older Adults With Multiple Sclerosis

Associations between diet and disease progression and symptomatology in multiple sclerosis: A systematic review of observational studies

*Bidirectional two-sample Mendelian randomization analysis identifies causal associations between oxidative stress and Parkinson's disease

Blueberry extracts antagonize Aβ25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus

**Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits

*Caffeine consumption outcomes on amyotrophic lateral sclerosis disease progression and cognition

*Caloric restriction leading to attenuation of experimental Alzheimer's disease results from alterations in gut microbiome

*'Citicoline' and support of the memory function: Evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

*Coffee polyphenols ameliorate early-life stress-induced cognitive deficits in male mice

*Cognitive Disorders in Chronic Kidney Disease: We Are What We Eat

Cognitive impairment and the gut-brain axis during 2014-2023: a bibliometric analysis

Contribution of Nutritional, Lifestyle, and Metabolic Risk Factors to Parkinson's Disease

Current practices in the nutrition management of people with amyotrophic lateral sclerosis (ALS): a survey of U.S. ALS care teams

*DHA dietary intervention caused different hippocampal lipid and protein profile in ApoE-/- and C57BL/6J mice

**Dietary polyphenols represent a phytotherapeutic alternative for gut dysbiosis associated neurodegeneration: A systematic review

Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission

Dietary quality and the gut microbiome in early-stage Parkinson's disease patients

*Effects of a multidomain intervention against cognitive decline on dementia risk profiles - Results from the AgeWell.de trial

*Effects of Anthocyanins on Cognition and Vascular Function: A Systematic Review

*Effects of Ferulic Acid on Cognitive Function: A Systematic Review

*Exploring the Therapeutic Potential of Benfotiamine in a Sporadic Alzheimer's-Like Disease Rat Model: Insights into Insulin Signaling and Cognitive function

*Food quality influences behavioural flexibility and cognition in wild house mice

*Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model

Hop (Humulus lupulus L.) extract reverts glycaemic imbalance and cognitive impairment in an animal model of obesity

*Identification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis

*Impact of food insecurity on cognitive health in older adults: insights from the NHANES 2011-2014 data

The influence of time-restricted eating/feeding on Alzheimer's biomarkers and gut microbiota

Interaction between the Neuroprotective and Hyperglycemia Mitigation Effects of Walnut-Derived Peptide LVRL via the Wnt3a/β-Catenin/GSK-3β Pathway in a Type 2 Diabetes Mellitus Model

Investigating the effects of 25-hydroxyvitamin D3 on clinical outcomes in multiple sclerosis patients: A randomized, double-blind clinical trial- a pilot study

*Investigating the therapeutic effects of a Japanese sake yeast supplement on a zebrafish model of Parkinson's disease: Antioxidant and inflammatory responses

Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta

Lutein and the Underlying Neuroprotective Promise against Neurodegenerative Diseases

*Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection

*Magnesium and Cognitive Health in Adults: A Systematic Review and Meta-Analysis

*A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case-Control Analysis Nested within the Three-City Cohort Study

Mitochondrial sirtuin 3 and role of natural compounds: the effect of post-translational modifications on cellular metabolism

*Modulation of microglia activation by the ascorbic acid transporter SVCT2

The multifaceted effects of flavonoids on neuroplasticity

New horizons for the role of selenium on cognitive function: advances and challenges

*Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer's disease: Multimodal Preventive Trial for Alzheimer's Disease (MIND-ADmini)

*Nutrition interventions for body composition, physical function, cognition in hospitalized older adults: A systematic review of individuals 75 years and older

*Nutritional status, dietary quality and eating disturbance issues among people with dementia in Vietnam: evidence of a cross-sectional study

*Omega-3 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia

**Pro-inflammatory protein S100A9 targeted by a natural molecule to prevent neurodegeneration onset

The protective effect of biotin supplementation and swimming training on cognitive impairment and mental symptoms in a rat model of Alzheimer's disease: A behavioral, biochemical, and histological study

The protective role of interaction between vitamin D, sex hormones and calcium in multiple sclerosis

*Role of Artificial Intelligence in Multinomial Decisions and Preventative Nutrition in Alzheimer's Disease

Supporting Mealtime Participation Among People Living With Dementia at Home: Challenges and Strategies for Caregivers

Synbiotic therapy with Clostridium sporogenes and xylan promotes gut-derived indole-3-propionic acid and improves cognitive impairments in an Alzheimer's disease mouse model

Synergistic effects of tilapia head protein hydrolysate and walnut protein hydrolysate on the amelioration of cognitive impairment in mice

*Systemic inflammation, lifestyle behaviours and dementia: A 10-year follow-up investigation

**Tannic acid as a biphasic modulator of tau protein liquid-liquid phase separation

Therapeutic potential of curcumin on the cognitive decline in animal models of Alzheimer's disease: a systematic review and meta-analysis

Treatment with walnut peptide ameliorates memory impairment in zebrafish and rats: promoting the expression of neurotrophic factors and suppressing oxidative stress

Mood and Mental Health

*A holistic lifestyle mobile health intervention for the prevention of type 2 diabetes and common mental disorders in Asian women with a history of gestational diabetes: a randomised control trial with 3-year follow-up protocol

*Adolescent Mental Health and Suicidal Behaviors in the Context of Expanded Supplemental Nutrition Assistance Program Eligibility

*Adherence to the EAT-lancet diet and incident depression and anxiety

Assessing the role of antioxidant and pro-oxidant balance in mediating the relationship between vitamin K intake and depressive symptoms in adults

*Association between 29 food groups of diet quality questionnaire and perceived stress in Chinese adults: a prospective study from China health and nutrition survey

The association between plant and animal protein intake with depression, anxiety, and stress

*Association between polyunsaturated fatty acids and depression in women with infertility: a cross-sectional study based on the National Health and Nutrition Examination Survey

**The association between soft drinks consumption and risk of mental disorders among Iranian adults: The LIPOKAP study

*Association between the adherence to Mediterranean diet and depression in rheumatoid arthritis patients: a cross-sectional study from the NHANES database

*Association between vitamin A intake and depression among patients with heart failure

The association of the Prime Diet Quality Score (PDQS) with depression and anxiety symptoms: the Isfahan functional disorders (ISFUN) cohort study

Associations between Early-pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms

*Associations Between Vitamin D Deficiency/Insufficiency and Depression Expose Health Disparities in Older Rural West Texans: A Project FRONTIER Study

*Causal associations between vitamin D and postpartum depression: A bidirectional mendelian randomization study

*Dietary inflammation, sleep and mental health in the United Kingdom and Japan: A comparative cross-sectional study

*The Effect of Genetic Variations in the Vitamin D Receptor Gene on the Course of Depressive Symptoms

*Effect of high fat diet on maternal behavior, brain-derived neurotrophic factor and neural stem cell proliferation in mice expressing human placental lactogen during pregnancy

*Influence of lifestyle patterns on depression among adults with diabetes: a mediation effect of dietary inflammatory index

*Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson's Disease

*Investigating the role of obesity, circadian disturbances and lifestyle factors in people with schizophrenia and bipolar disorder: Study protocol for the SOMBER trial

*Investigations of microbiota composition and neuroactive pathways in association with symptoms of stress and depression in a cohort of healthy women

*Iron and n-3 fatty acid depletion, alone and in combination, during early development provoke neurochemical changes, anhedonia, anxiety and social dysfunction in rats

Is a vegetarian diet beneficial for bipolar disorder? Relationship between dietary patterns, exercise and pharmacological treatments with metabolic syndrome and course of disease in bipolar disorder

**Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome

Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis)

Mitigation and mechanism of low dose linoleic acid on depression caused by disorder of gut microbiome

**A network pharmacology-based method to explore the therapeutic effect of honokiol on diabetes with comorbid depression in mice

*Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression

Overall diet quality, food groups and mental health disorders among Brazilians older than 15 years old: Brazilian National Health Survey - 2019

**Pilot study indicates that a gluten-free diet lowers oxidative stress for gluten-sensitive persons with schizophrenia

*Positive and negative schizotypy personality traits are lower in individuals on ketogenic diet in a non-clinical sample

The Possible Neuroprotective Effect of Caffeic Acid on Cognitive Changes and Anxiety-Like Behavior Occurring in Young Rats Fed on High-Fat Diet and Exposed to Chronic Stress: Role of β-Catenin/GSK-3B Pathway

*The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review

**The relationship between different fatty acids intake and the depressive symptoms: A population-based study

*Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus

Stevioside Ameliorates Prenatal Obesity Induced Postpartum Depression: The Potential Role of Gut Barrier Homeostasis

*Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analyses

*Vitamin-mediated interaction between the gut microbiome and mitochondria in depression: A systematic review-based integrated perspective

Eating Disorders

*A naturalistic study of plasma lipid alterations in female patients with anorexia nervosa before and after weight restoration treatment

Behaviourally assessed negative urgency is uniquely associated with binge-eating frequency

*Brief cognitive behavioural therapy for eating disorders symptomatology among a mixed sample of adolescents and young adults in primary care: A non-randomised feasibility and pilot study

Building Confidence in Discussing Genetics With Patients With Eating Disorders and Their Families

*Diagnosed eating disorders in Danish registers - incidence, prevalence, mortality, and polygenic risk

*The impact of low-energy total diet replacement with behavioural support for remission of type 2 diabetes on disordered eating (ARIADNE): Protocol for a non-inferiority randomised controlled trial

*Influence of the COVID-19 pandemic on the incidence of eating disorders

Innovative and Emerging Treatments for Anorexia Nervosa

Medical Considerations and Consequences of Eating Disorders

*The Modeled Cost-Effectiveness of a Prevention Program Targeting Both Eating Disorders and High BMI

*Overcoming Barriers in Eating Disorder Care: Advances, Gaps, and Recommendations for Equitable Assessment and Treatment

*Physical health complications in children and young people with avoidant restrictive food intake disorder (ARFID): a systematic review and meta-analysis

*Secondary carnitine deficiency during refeeding in severely malnourished patients with eating disorders: a retrospective cohort study

*Striving for the perfect diet? The mediating role of perfectionism in the relationship between obsessive compulsive symptoms and traits of Orthorexia Nervosa

*Stomach size in anorexia nervosa: A new challenge?

Trajectories and predictive factors of weight recovery in patients with anorexia nervosa completing treatment. A latent class mixed model approach

*Xeropthalmia and optic neuropathy secondary to ARFID: a case report

What Next for Eating Disorder Genetics? Replacing Myths With Facts to Sharpen Our Understanding

*Who gets treated for an eating disorder? Implications for inference based on clinical populations

Addiction, Eating Behavior and Food Choice

*Editorial: Neurobiology of eating behavior: insights into adiposity and cardiometabolic health

*Effects of Highly Palatable Diet on motivation for food and resistance to punishment in rats: Role of sex and age of exposure

Emotional Eating Prevalence and Correlates in Adolescents in the United States

*An exploratory study of factors in disordered eating behavior in diabetes self-management in Japan

*Food-related inhibitory control deficits in young male adults with obesity: Behavioral and ERP evidence from a food-related go/no-go task

*Hedonic hunger, ultra-processed food consumption, and the moderating effects of impulsivity in pregnant individuals with body mass index ≥ 25

*I'll have what She's having (but not what They're having): The moderating role of group membership in the effect of social norms on food choice in an online environment

*Motivational profiles for eating behavior and their associations with intuitive eating

*Nudging towards sustainable dining: Exploring menu nudges to promote vegetarian meal choices in restaurants

*Obesity- and diet-induced plasticity in systems that control eating and energy balance

*Selenium supplementation via modulation of selenoproteins ameliorates binge drinking-induced oxidative, energetic, metabolic, and endocrine imbalance in adolescent rats' skeletal muscle

Neurodevelopmental Outcomes

Abnormal Porphyrin Metabolism in Autism Spectrum Disorder and Therapeutic Implications

*Adherence to the Mediterranean diet during pregnancy and behavioural problems at 4 years of age

*Association of Maternal Fish Consumption and Omega-3 Supplement Use During Pregnancy With Child Autism-Related Outcomes: Results from a Cohort Consortium Analysis

Beneficial effects of dietary omega 3 polyunsaturated fatty acids on offspring brain development in gestational diabetes mellitus

**Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring

*Complementary and Alternative Medicine for Autism - A Systematic Review

Early-life malnutrition role in memory, emotional behavior and motor impairments in early brain lesions with potential for neurodevelopmental disorders: a systematic review with meta-analysis

*Early nutritional influences on brain regions related to processing speed in children born preterm: A secondary analysis of a randomized trial

Folic acid and autism: updated evidences

*Food, nutrition, and autism: from soil to fork

*Gestational bisphenol A exposure alters energy homeostasis and adult hypothalamic neurogenesis in female mice

*Healthy Prenatal Dietary Pattern and Offspring Autism

**High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration

*Infant formula supplemented with milk fat globule membrane compared with standard infant formula for the cognitive development of healthy term-born formula-fed infants: protocol for a randomised controlled trial

Intermittent Fasting Improves Social Interaction and Decreases Inflammatory Markers in Cortex and Hippocampus

Iron Supplementation in Management of Neurodevelopmental Disorders: Systematic Review, Meta-Analysis, and Qualitative Synthesis

Mechanistic perspective on the actions of vitamin a in autism spectrum disorder etiology

"Still work?" Design and effect of interventions used to modify feeding problems in children with autism: A systematic review of studies employing group designs

The relation between MIND diet with odds of attention-deficit/hyperactivity disorder in Iranian children: a case-control study

The relationship between adherence to the Mediterranean dietary pattern during early pregnancy and behavioral, mood and cognitive development in children under 1 year of age: a prospective cohort study

Vitamin D3 Supplementation and Aquatic Exercise Combination as a Safe- Efficient Therapeutic Strategy to Ameliorate Interleukin-6 and 10, and Social Interaction in Children with Autism

Sleep Health and Insomnia

*Associations of dietary patterns with objective and subjective sleep duration and sleep quality in a population-based cohort study

*Dietary Intake of Nutrients Involved in Serotonin and Melatonin Synthesis and Prenatal Maternal Sleep Quality and Affective Symptoms

Brain Injury

**High-fat diet consumption negatively influences closed-head traumatic brain injury in a pediatric rodent model

Thiamine use is associated with better outcomes for traumatic brain injury patients

Vitamin D Supplementation in Functional Recovery of Subjects with Severe Acquired Brain Injury: A Pilot Controlled Randomized Study

Migraines, Epilepsy and Other Neurological

Associations between diet quality and migraine headaches: a cross-sectional study

*Celiac disease with neurological manifestations mimicking stiff-person syndrome

Correlation analysis of 25(OH)D with cognitive function in epilepsy patients: A cross-sectional study

Diet-derived circulating antioxidants and risk of epilepsy: a Mendelian randomization study

Involuntary Movements in Cobalamin Deficiency

Ketogenic diet therapy leads to antiseizure medication reduction in children and adults with drug-resistant epilepsy

Menaquinone-4 Alleviates Neurological Deficits Associated with Intracerebral Hemorrhage by Preserving Corticospinal Tract in Mice

Migraine and Epilepsy in Children: A Narrative Review of Comorbidity and Similar Treatment Option

*Poor Adherence to the Mediterranean Diet and Sleep Disturbances Are Associated with Migraine Chronification and Disability among an Adult Population in the Lazio Region, Italy

*Prospective study of the modified Atkins diet in adult drug-resistant epilepsy: effectiveness, tolerability, and adherence

*Riboflavin transporter deficiency in young adults unmasked by dietary changes

*Triptan treatment is associated with a higher number of red wine-induced migraine episodes: An exploratory questionnaire-based survey

Unlocking Dietary Strategies to Combat Neurological Disorders

*Vitamin D deficiency and effect of treatment on seizure frequency and quality of life parameters in patients with drug-resistant epilepsy: A randomized clinical trial

Wernicke's encephalopathy treated with high dose intravenous thiamine: a case report

Other

Correction to: Role of vitamin D in the association between pre‑stroke sleep quality and post-stroke depression and anxiety

*Milestone review: GABA, from chemistry, conformations, ionotropic receptors, modulators, epilepsy, flavonoids, and stress to neuro-nutraceuticals

**Vitamin D attenuates monosodium glutamate-induced behavioural anomalies, metabolic dysregulation, cholinergic impairment, oxidative stress, and astrogliosis in rats

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Copyright © 2024 Sarah Thomsen Ferreira.