Brain Food Digest: August 2024

What's New in Nutrition and Brain Health

Today's research summary includes 175+ publications, with topics including:

• associations between different diet quality scores and depression risk

• the effect of probiotics as an adjunctive therapy with Ritalin among ADHD children and adolescents

• impact in pre-clinical models of increasing one-carbon metabolites on traumatic brain injury outcome

Key: *Full text available **Section summaries available

Inclusive of publication dates August 1-31, 2024.

Insights or suggestions? Hit reply to let me know.

Sarah Ferreira, MS, MPH, RD

Research Area

• Cognitive Function, Memory and Neurodegeneration

• Mood and Mental Health

• Eating Disorders

• Addiction, Alcohol Use, Eating Behavior and Food …

• Neurodevelopmental Outcomes

• Sleep Health and Insomnia

• Brain Injury

• Migraines, Epilepsy and Other Neurological

• Other

Cognitive Function, Memory and Neurodegeneration

Alternate-day fasting improves cognitive and brain energy deficits by promoting ketone metabolism in the 3xTg mouse model of Alzheimer's disease

*Anti-Inflammatory Diet and Dementia in Older Adults With Cardiometabolic Diseases

*Association between dietary magnesium intake, inflammation, and neurodegeneration

The Association between Individual Food Groups, Limbic System White Matter Tracts, and Episodic Memory: Initial Data from the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study

*Association between Life's Essential 8 and cognitive function among older adults in the United States

Associations between dietary one-carbon metabolism nutrients, genetic risk, with Alzheimer's disease: a prospective cohort study

**Associations Between Different Coffee Types, Neurodegenerative Diseases, and Related Mortality: Findings from a Large Prospective Cohort Study

Associations of empirically derived dietary patterns and cognitive performance in older men: Results of the Osteoporotic Fractures in Men (MrOS) study

*Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer's Disease

*Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders

Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease

The Characterization of the Th1/Th2 Ratio in Multiple Sclerosis Patients and its Response to a Dietary Supplement Regimen

Chronic administration of prebiotics and probiotics ameliorates pathophysiological hallmarks of Alzheimer's disease in a APP/PS1 transgenic mouse model

*Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study

The complex relationship between late-onset caloric restriction and synaptic plasticity in aged Wistar rats

Dietary patterns, inflammatory biomarkers and cognition in older adults: An analysis of three population-based cohorts

*Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer's disease

Editorial: Ketogenic diets for cognitive and behavioral function

Educommunication in Nutrition and Neurodegenerative Diseases: A Scoping Review

*The effect of whole-diet interventions on memory and cognitive function in healthy older adults - a systematic review

Effects of APOE4 on omega-3 brain metabolism across the lifespan

*Effectiveness of exercise interventions, alone or in combination with dietary modifications, on working memory in overweight and obese individuals: A systematic review

The Effects of Epigallocatechin-3-Gallate Nutritional Supplementation in the Management of Multiple Sclerosis: A Systematic Review of Clinical Trials

*Effects of MIND diet and propolis supplementation on metabolic syndrome indices and cognitive function among patients with metabolic syndrome in Isfahan, Iran, 2024. A rationale and study protocol for randomized controlled trial

*Efficacy of therapeutic intervention with NanoBEO to manage agitation and pain in patients suffering from severe dementia: a pilot clinical trial

Egg Consumption and 4-Year Change in Cognitive Function in Older Men and Women: The Rancho Bernardo Study

Exploring the molecular mechanisms underlying neuroprotective effect of ellagic acid in okadaic acid-induced Alzheimer's phenotype

*Fatty acid amides present in Camembert cheese improved cognitive decline after oral administration in mice

*Feeding and Nutrition for People with Dementia in Gerontological Services: A Focus Group Study

*Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies

*Healthy Dietary Pattern Improves Cognitive Function in Elderly Persons With Periodontitis: A Cross-Sectional Study of NHANES

*High-fat diet and aging-associated memory impairments persist in the absence of microglia in female rats

High use of non-hydrogenated plant source oils and mayonnaise sauce increase the risk of Parkinson disease

Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer's Disease-Related Markers in Male Mice

*Lactococcus strains with psychobiotic properties improve cognitive and mood alterations in aged mice

*Long-term d-allose administration ameliorates age-related cognitive impairment and loss of bone strength in male mice

**Long-term exposure to advanced lipid peroxidation end products impairs cognitive function through microbiota-gut-brain axis

Malnutrition in Amyotrophic Lateral Sclerosis: Insights from Morphofunctional Assessment and Global Leadership Initiative on Malnutrition Criteria

*The Mediterranean diet is not associated with neuroimaging or cognition in middle-aged adults: a cross-sectional analysis of the PREVENT dementia programme

*Microbiome and micronutrient in ALS: From novel mechanisms to new treatments

*The MIND diet, brain transcriptomic alterations, and dementia

*Navigating Prevention: A Systematic Review of Strategies for Alzheimer's Disease in High-Risk and Affected Individuals

*Neurodegenerative diseases and catechins: (-)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress

Non-Linear Association of Dietary Polyamines with the Risk of Incident Dementia: Results from Population-Based Cohort of the UK Biobank

Paraoxonase I Activity and Its Relationship with Nutrition in Amyotrophic Lateral Sclerosis

Personalized Paths: Unlocking Alzheimer's via the Gut-Brain Axis

Plant but not animal sourced nitrate intake is associated with lower dementia-related mortality in the Australian Diabetes, Obesity, and Lifestyle Study

*Prebiotics mitigate the detrimental effects of High-Fat diet on Memory, anxiety and microglia functionality in ageing mice

Proteomic analysis of baicalin intervention on protein expression and modification in the hippocampus of Alzheimer's disease model rat

*Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis

*Relationship between oral status, swallowing function, and nutritional risk in older people with and without Parkinson's disease

Reversible dementia and seizures due to metformin-induced vitamin B12 deficiency

Reversal of high-fat diet-induced cognitive impairment and oxidative stress in the brain through Zingiber officinale supplementation

The Role of 25-OH Vitamin D in Alzheimer's Disease through Mendelian Randomization and MRI

**The roles of dietary polyphenols at crosstalk between type 2 diabetes and Alzheimer's disease in ameliorating oxidative stress and mitochondrial dysfunction via PI3K/Akt signaling pathways

*Scheduled feeding improves sleep in a mouse model of Huntington's disease

Select Dietary Components Are Associated With Better Global Cognition in U.S. Adults With HIV: A Pilot Study

*Serum 25-hydroxyvitamin D concentrations and their impact on all-cause mortality in Parkinson's disease: insights from National Health and Nutrition Examination Survey 1999-2020 data

Supplementation with Bifidobacterium animalis subsp. lactis MH-022 for remission of motor impairments in a 6-OHDA-induced Parkinson's disease rat model by reducing inflammation, reshaping the gut microbiome, and fostering specific microbial taxa

*Unlocking the Potential of Low-Molecular-Weight (Poly)phenol Metabolites: Protectors at the Blood-Brain Barrier Frontier

Vicious cycle of oxidative stress and neuroinflammation in pathophysiology of chronic vascular encephalopathy

Western diet-induced cognitive and metabolic dysfunctions in aged mice are prevented by rosmarinic acid in a sex-dependent fashion

**Yeast β-glucan alleviates high-fat diet-induced Alzheimer's disease-like pathologies in rats via the gut-brain axis

Mood and Mental Health

Adherence to the Mediterranean diet and depressive, anxiety, and stress symptoms in Spanish adolescents: results from the EHDLA study

Ameliorating Effect of Standardized Rice Bran Supplement on Depressive-Like Behaviors in Ovariectomized Mice

An Anti-Inflammatory Diet and Its Potential Benefit for Individuals with Mental Disorders and Neurodegenerative Diseases-A Narrative Review

*Association between dietary patterns and depression symptoms among adults with or without diabetes in Qatar: a population-based study

**Association between dietary spermidine intake and depressive symptoms among US adults: National Health and Nutrition Examination Survey (NHANES) 2005-2014

*Association between different diet quality scores and depression risk: the REGICOR population-based cohort study

Association of circulation very long chain saturated fatty acids with depression in NHANES 2011-2014

Association of dietary antioxidant intake with depression risk and all-cause mortality in people with prediabetes

**Association of dietary vitamin C intake with depression in adults: A cross-sectional study of NHANES from 2005 to 2020

**The associations between dietary flavonoids intake and risk of depressive symptom in diabetic patients: Data from NHANES 2007-2008, 2009-2010, and 2017-2018

*Associations between fruit and vegetable intakes and incident depression in middle-aged and older adults from 10 diverse international longitudinal cohorts

*Associations Between Vitamin K and Suicide Attempts in Patients with Depression: A Case-Control Study [Response to Letter]

**Associations of the intake of individual and multiple fatty acids with depressive symptoms among adults in NHANES 2007–2018

Bridging the gap: Prenatal nutrition, myelination, and schizophrenia etiopathogenesis

**Circulating B vitamins metabolites in depressive disorders - connections with the microbiota-gut-brain axis

Comparative analysis of nutritional status among institutionalised and community-dwelling elderly women and its association with mental health status and cognitive function

Depression and diet quality, US adolescents and young adults: National Health and Nutrition Examination Survey, 2015-March 2020

*Diet quality and associations with lactate and metabolic syndrome in bipolar disorder

**Differential effects of high-fat diet on endocrine, metabolic and depressive-like behaviors in male and female rats

Early protein restriction in rats induces anhedonia in adult offspring: A key role of BDNF-TrkB signaling in the nucleus accumbens shell

The effect of a low-calorie, high-protein diet on psychometric variables in obese individuals: a Randomized Clinical Trial.

The Effects of Caloric Restriction and Clinical Psychological Intervention on the Interplay of Gut Microbial Composition and Stress in Women

The effects of ketogenic metabolic therapy on mental health and metabolic outcomes in schizophrenia and bipolar disorder: a randomized controlled clinical trial protocol

*Effects of time-restricted eating and low-carbohydrate diet on psychosocial health and appetite in individuals with metabolic syndrome: A secondary analysis of a randomized controlled trial

Feeding gut microbes to nourish the brain: unravelling the diet-microbiota-gut-brain axis

**Fish consumption and depression in Korean population: The Korea National Health and Nutrition Examination Survey, 2013-2021

*The Impact of a Diet Rich in Omega-3 Fatty Acids on the Quality of Life of Patients with Squamous Cell Lung Cancer and Comorbid Depression: A Retrospective Study

*Independent and combined effect of serum copper and folate on depression: cross-sectional data from the NHANES 2011-2016

*Ketogenic diet has a positive association with mental and emotional well-being in the general population

*Milk fat globule membranes for psychological and physical health: qualitative results from the Employing Milk Phospholipids to Observe Well-being and Emotional Resilience (EMPOWER) randomised trial

**Neurolipidomics in schizophrenia: a not so well-oiled machine

Nutritional Strategies in Major Depression Disorder: From Ketogenic Diet to Modulation of the Microbiota-Gut-Brain Axis

Omega-3 Supplementation Reduces Schizotypal Personality in Children: A Randomized Controlled Trial

*Progress and trends of research on mineral elements for depression

Quercetin alleviates depressive-like behavior by modulating acetyl-H3K9 mediated ferroptosis pathway in hypothalamus of perimenopausal depression rat model

*Retrospective case study: ketogenic metabolic therapy in the effective management of treatment-resistant depressive symptoms in bipolar disorder

The role of dietary intake of live microbes in the association between leisure-time physical activity and depressive symptoms: a population-based study

Targeting Divergent Pathways in the Nutritional Management of Depression

Untargeted Metabolomics Revealed that Quercetin Inhibited Ferroptosis by Improving Metabolic Disorder in the Hippocampus of Perimenopausal Depression Model Rats

Vitamin D Deficiency in the Acute Phase of Stroke May Predict Post-stroke Depression: A Systematic Review and Meta-Analysis

**Vitamin D deficiency may exacerbate the role of metal exposure in depression: A cross-sectional analysis of NHANES data from 2007 to 2018

Eating Disorders

An advanced Artificial Intelligence platform for a personalised treatment of Eating Disorders

Anorexia and Bulimia Nervosa in Spanish Middle-Aged Adults: Links to Sociodemographic Factors, Diet, and Lifestyle

*Assessing Avoidant/Restrictive Food Intake Disorder (ARFID) Symptoms Using the Nine Item ARFID Screen in >9000 Swedish Adults With and Without Eating Disorders

*Associations between dieting practices and eating disorder attitudes and behaviors: Results from the Canadian study of adolescent health behaviors

*Barriers and facilitators to ethical co-production with Autistic people with an eating disorder

Blood Parameters in Children and Adolescents With Underweight and Atypical Anorexia Nervosa

The Development and Validation of a Disordered Eating Screening Tool for Current and Former Athletes: The Athletic Disordered Eating (ADE) Screening Tool

Editorial: Limitations on the Predictive Validity of the ARFID Diagnosis

*The effect of cinnamon supplementation on eating disorder indices among people suffering from binge eating disorder: a randomized controlled trial

Exploring the continuum of eating behaviour, from 'normal' to disordered eatin

Identifying potential cases of eating disorders in an acute medical hospital

**Impact of COVID-19 restrictive measures during lockdown period on eating disorders: An umbrella review

The Impact of Following Instagram Influencers on Women's Body Dissatisfaction and Eating Disorder Symptoms

Management of eating disorders during pregnancy: A survey of Australian dietitians in clinical practice

Novel Guided Self-Help for the treatment of Binge Eating Disorder: Feasibility, Acceptability, and Preliminary Efficacy

A pilot study evaluating online training for therapist delivery of interpersonal psychotherapy for eating disorders

Predicting and comparing the long-term impact of lifestyle interventions on individuals with eating disorders in active population: a machine learning evaluation

Recreational Physical Activity and the Mediterranean Diet: Their Effects on Obesity-Related Body Image Dissatisfaction and Eating Disorders

*Symptoms of Depression, Eating Disorders, and Binge Eating in Adolescents With Obesity: The Fast Track to Health Randomized Clinical Trial

A Systematic Review on the Prevalence and Risk of Orthorexia Nervosa in Health Workers and Students

*Vitamin D Status and Behavioral Impulsivity in Anorexia Nervosa: Insights from a Longitudinal Study

Addiction, Alcohol Use, Eating Behavior and Food Choice

*Alx3 deficiency disrupts energy homeostasis, alters body composition, and impairs hypothalamic regulation of food intake

Associations of sugar-related food parenting practices and parental feeding styles with prospective dietary behavior of children and adolescents: a systematic review of the literature from 2017 to 2023

**Development and validation of the mindful eating scale (mind-eat scale) in a general population

*Diet modifies the association between alcohol consumption and severe alcohol-related liver disease incidence

*The effectiveness of the TRACE online nutrition intervention in improving dietary intake, sleep quality and physical activity levels for Australian adults with food addiction: a randomised controlled trial

Effects of Probiotic Supplementation Added to a Weight Loss Program on Anthropometric Measures, Body Composition, Eating Behavior, and Related Hormone Levels in Patients with Food Addiction and Weight Regain After Bariatric Surgery: A Randomized Clinical Trial

Effects of Several Tea-like Plants on Liver Injury Induced by Alcohol via Their Antioxidation, Anti-Inflammation, and Regulation of Gut Microbiota

**Electrophysiological and behavioral differences of general and food-specific inhibitory control in people with different levels of intuitive eating

Genes Involved in Susceptibility to Obesity and Emotional Eating Behavior in a Romanian Population

The gut-immune-liver axis in patients with alcohol use disorder and clinically low serum zinc levels

**Mechanisms underlying food devaluation after response inhibition to food

More Frequent Solitary Alcohol Consumption Is Associated With Poorer Diet Quality, Worse Sleep, Higher Body Mass Index, and More Problematic Alcohol Use

*A qualitative exploration of food choice motives of urban indigenous food gatekeepers in Fiji: Implications for the use of the food choice questionnaire

Regulation of craving training to support healthy food choices under stress: A randomized control trial employing the hierarchical drift-diffusion model

The relationship between perceived stress and emotional eating in bus drivers: the effect of shift work

A picture is worth a thousand words: Framing of food choice options affects decision conflict and mid-fontal theta in food choice task

*Self-reported alcohol consumption during participation in a text messaging-based online drinking moderation platform

**Vitamin B12 supplementation improved memory impairment following nicotine withdrawal in adolescent male rats: The role of oxidative stress, inflammatory, BDNF, GFAP, and AChE activity

Neurodevelopmental Outcomes

Association Between Food Insecurity and Developmental Delay and Behavioral Problems in US Children 2 to 5 Years of Age

**Associations of prenatal exposure to individual and mixed organophosphate esters with ADHD symptom trajectories in preschool children: The modifying effects of maternal Vitamin D

*Breastfeeding patterns in infants are associated with a later diagnosis of autism Spectrum disorder

Choline chloride shows gender-dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide-induced rat model of autism

The complex interplay between autism spectrum disorder and gut microbiota in children: A comprehensive review

Dietary sn-2 palmitate influences cognitive behavior by increasing the transport of liver-produced lysophosphatidylcholine VLCPUFAs to the brain

**Effect of probiotics as an adjunctive therapy with Ritalin among ADHD children and adolescents: a triple-blind randomized controlled trial

Extraction, Phytochemical profile, and neuroprotective activity of Phyllanthus emblica fruit extract against sodium valproate-induced postnatal autism in BALB/c mice

Feeding-Related Early Signs of Autism Spectrum Disorder: A Narrative Review

Gut microbiota, vitamin A deficiency and autism spectrum disorder: an interconnected trio - a systematic review

*Informing creation of the FEEDS Toolkit to support parent-delivered interventions for eating, drinking and swallowing difficulties in young children with neurodisability: intervention use by neurodevelopmental diagnosis and healthcare professional role

Is an Exclusive Human Milk Diet at the Time of Neonatal Intensive Care Unit Discharge Adequate to Maintain Growth and Neurodevelopment among Very Preterm Infants?

*Long-term saturated fat-enriched diets impair hippocampal learning and memory processes in a sex-dependent manner

*Maternal high-fat or low-protein diets promote autism-related behavior and altered social behavior within groups in offspring male mice

Maternal low-dose caffeine intake during the perinatal period promotes short- and long-term sex-dependent hormonal and behavior changes in the offspring

*Maternal selenium deficiency during pregnancy in association with autism and ADHD traits in children: The Odense Child Cohort

**Neurodevelopmental changes in Drosophila melanogaster are restored by treatment with lutein-loaded nanoparticles: Positive modulation of neurochemical and behavioral parameters

The neuroprotective effect of vitamin D in Parkinson's disease: association or causation

*Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder

**Socioeconomic adversity, maternal nutrition, and the prenatal programming of offspring cognition and language at two years of age through maternal inflammation

Vitamin D status in pregnancy and cord blood is associated with symptoms of attention-deficit hyperactivity disorder at age 5 years: Results from Odense Child Cohort

Sleep Health and Insomnia

**Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study

*Causal Relationship Between Micronutrient and Sleep Disorder: A Mendelian Randomization Study

*Chrono-nutrition and sleep: lessons from the temporal feature of eating patterns in human studies - A systematic scoping review

The effects of ketogenic dietary therapies on sleep: A scoping review.

*Iron Deficiency and Sleep/Wake Behaviors: A Scoping Review of Clinical Practice Guidelines-How to Overcome the Current Conundrum?

Brain Injury

*Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

Migraines, Epilepsy and Other Neurological

A side-by-side comparison of fine-tuning options for treatment of medically refractory epilepsy: Antiseizure medications, vagus nerve stimulation and ketogenic diet therapies

*Advances in the study of gut microbes in pediatric epilepsy

*Association between composite dietary antioxidant index and epilepsy in American population: a cross-sectional study from NHANES

*Association between the Composite Dietary Antioxidant Index and severe headache or migraine: results from the National Health and Nutrition Examination Survey

*Author Correction: Association of dietary and lifestyle inflammation score (DLIS) with chronic migraine in women: a cross-sectional study

*Development and psychometric evaluation of the epilepsy lifestyle questionnaire

**Efficacy and tolerability of classical and polyunsaturated fatty acids ketogenic diet in controlling paediatric refractory epilepsy - A randomized study

*Efficacy of anti-seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1-related epilepsy: A systematic review

*Evaluating the serum levels of zinc, copper, magnesium, and 25-hydroxy vitamin D in children with idiopathic drug-resistant epilepsy; a cross-sectional study

Factors associated with seizure response in adults with epilepsy on a modified Atkins diet

* Maintenance of response to ketogenic diet therapy for drug-resistant epilepsy post diet discontinuation: A multi-centre case note review

Neuroprotective role of chlorogenic acid against hippocampal neuroinflammation, oxidative stress, and apoptosis following acute seizures induced by pentylenetetrazole

Nice to know 2: The impact of NICE guidelines on ketogenic diet services in the UK and Ireland - An update

*Nurture growth: Ketogenic diet therapy and growth velocity in infants under 12 months with epilepsy - A systematic review and infant data study

Optimizing ketogenic diet therapy for childhood epilepsy: Identifying key factors for seizure control and psychomotor enhancement

*Outcomes of Percutaneous Endoscopic Gastrostomy in Huntington's Disease at a Tertiary Center

Percutaneous gastrostomy, mechanical ventilation and survival in amyotrophic lateral sclerosis: an observational study in an incident cohort

*Telemedicine in nutritional management of children with severe neurological impairment: implication for quality of life

Volume-based enteral feeding for ward patients with acute neurological conditions: a pilot prospective cohort study

Other

Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology

*Comparative Neuroprotective Potential of Nanoformulated and Free Resveratrol Against Cuprizone-Induced Demyelination in Rats

*Dietary galactose exacerbates autoimmune neuroinflammation via advanced glycation end product-mediated neurodegeneration

*Exploring the ketogenic diet’s potential in reducing neuroinflammation and modulating immune responses

*Fasting-induced activity changes in MC3R neurons of the paraventricular nucleus of the thalamus

*Short-term starvation activates AMPK and restores mitochondrial inorganic polyphosphate, but fails to reverse associated neuronal senescence

*Two-month ketogenic diet alters systemic and brain metabolism in middle-aged female mice

**Unraveling brain palmitic acid: Origin, levels and metabolic fate

Disclaimer: The information provided in this newsletter is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this newsletter. Reliance on any information provided in this newsletter is solely at your own risk. The authors and publishers of this newsletter are not liable for any losses, injuries, or damages arising from the use of the information provided.

Copyright © 2024 Sarah Thomsen Ferreira.